Depression

Definium Therapeutics has announced the strong Phase 3 results of its single-dosed lysergide drug DT120 in treating adults with major depressive disorder. It met its main goal and all key secondary efficacy endpoints in the first trial of its kind.

A common laxative may do more than aid digestion: it could sharpen memory and attention in people with depression. This existing drug, currently used to treat chronic constipation, has shown promise in tackling these often-overlooked cognitive issues.

Mental health content has not just risen in volume, it's changed significantly in just a few years. Some conditions have increasingly attracted the spotlight, while others have receded from view, and the relationships among them have also changed.

A recent study by researchers from the US biotech company Tuning Fork suggests that at least some cases of post-viral depression in people recovering from COVID-19 may have measurable biological underpinnings.

If you've wondered why you procrastinate with doing your taxes early or starting mundane jobs, it's not because you dislike them. New research has uncovered a specific pathway in the brain that slams the brakes on investing energy in these tasks.

Nitrous oxide, known as laughing gas, has shown rapid antidepressant effects in people with depression, with symptoms easing within hours of inhaling it. The treatment involves breathing in a mix of nitrous oxide and oxygen for up to an hour.

In a landmark shift in how mental health conditions are treated in the near future, the US Food and Drug Administration has approved the first at-home brain-stimulation device that can rapidly relieve moderate to severe depression symptoms.

There's a well-established link between depression and chronic low-grade inflammation. Now, a new meta-study shows that treating the inflammation can reduce depression in two ways, offering a potential alternative to antidepressants and their side effects.

In the most comprehensive investigation of the ketogenic diet’s mental health effects yet, researchers pooled 50 studies spanning six decades to see what we actually know about its influence on mood. The results are a mix of promising and uncertain.

Survivors of childhood trauma experience high risk for depression. If they have high levels of SGK1 in their brain tissue, they’re at greater risk. Combined with genetic screening for the protein, SGK1 inhibitors could be a life-saving intervention.

One of the brain’s biggest benefits from exercise – the birth of new neurons – may not even require any movement. Instead, the beneficial “packages” circulating in the blood after working out can be successfully transferred to others.

A new review reveals finasteride users face higher risks of depression, anxiety, and suicidal thoughts. Concerns about the drug's underreported mental health side effects prompt calls for stricter regulation.